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doi: 10.1371/journal.pone.0022806 22 KanwarYSSunLXiePLiuFYChenS

Reactive Oxygen Species (ROS) are increased by the consumption of sugars and oxidized vegetable oils, smoking, alcohol, exposure to environmental toxins, high or chronic emotional stress, circadian rhythm dysregulation (poor sleep), lack of exercise, infections, and a lack of antioxidant intake

However, its use in this case wasn't well established enough to pursue NAD for this use officially

Supplementing with the precise combination of NAC and glycine (GlyNAC) provides a highly targeted, orthomolecular intervention designed to break the relentless cycle of oxidative stress

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The math is simple, but you have to be meticulous